Document 0877
 DOCN  M9440877
 TI    Cytomegalovirus reactivation and tumour necrosis factor.
 DT    9404
 AU    Docke WD; Prosch S; Fietze E; Kimel V; Zuckermann H; Klug C; Syrbe U;
       Kruger DH; von Baehr R; Volk HD; Institute of Medical Immunology,
       Medical School-Charite,; Humboldt University, Berlin, Germany.
 SO    Lancet. 1994 Jan 29;343(8892):268-9. Unique Identifier : AIDSLINE
       MED/94125742
 AB    Tumour necrosis factor-alpha (TNF) stimulates cytomegalovirus (CMV)
       activity in a transfected human monocytic cell line. We assessed whether
       this finding is relevant in vivo by evaluating the frequency of active
       CMV infection in patients with diseases that enhance plasma TNF. In
       septic disease, peripheral blood mononuclear cells of almost all
       patients studied were positive for CMV. Furthermore, CMV antigenaemia
       and enhanced plasma TNF occurred in many patients with liver cirrhosis,
       common variable immunodeficiency, and B-cell chronic lymphocytic
       leukaemia. Thus, TNF may have a central role in CMV reactivation.
 DE    Adolescence  Adult  Antigens, Viral/*BLOOD  Case-Control Studies  Common
       Variable Immunodeficiency/BLOOD/COMPLICATIONS  *Cytomegalovirus/GROWTH &
       DEVELOPMENT/IMMUNOLOGY  Cytomegalovirus
       Infections/*BLOOD/COMPLICATIONS/MICROBIOLOGY  Female  Follow-Up Studies
       Human  Immunohistochemistry  Interleukin-6/BLOOD  Leukemia, B-Cell,
       Chronic/BLOOD/COMPLICATIONS  Leukocytes, Mononuclear/*MICROBIOLOGY
       Liver Cirrhosis/BLOOD/COMPLICATIONS  Male  Middle Age  Polymerase Chain
       Reaction  Recurrence  Septicemia/*BLOOD/COMPLICATIONS/MORTALITY
       Support, Non-U.S. Gov't  Tumor Necrosis Factor/*ANALYSIS  *Virus
       Activation  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).