Document 0901
 DOCN  M9440901
 TI    [Two cases of acquired immunodeficiency syndrome with disseminated
       non-tuberculous mycobacterial infection]
 DT    9404
 AU    Kishihara Y; Nakashima K; Nukina H; Hayashi J; Kashiwagi S; Department
       of General Medicine, Kyusyu University Hospital.
 SO    Kansenshogaku Zasshi. 1993 Dec;67(12):1223-7. Unique Identifier :
       AIDSLINE MED/94124915
 AB    Two cases of Acquired Immune Deficiency Syndrome (AIDS) with
       disseminated non-tuberculous mycobacterial infection are reported. Both
       patients had hemophilia and were infected with Human Immunodeficiency
       Virus type 1 (HIV) by antihemophilic factor infusion. In case 1, a
       44-year-old male, Mycobacterium marinum, which ordinarily causes
       cutaneous infection, was isolated from sputum before death and from the
       lung, spleen, bone marrow, liver and lymph node at autopsy. This is the
       first report of disseminated M. marinum infection with AIDS. In case 2,
       a 25-year-old male, Mycobacterium avium complex, which is the most
       common strain in non-tuberculous mycobacterial infection among patients
       with HIV, was isolated from the lung by TBLB and at autopsy from the
       lung, liver, spleen, bone marrow, lymph node, stomach, small intestine
       and testis. He also had a giant intraabdominal lymphadenopathy,
       associated with the M. avium complex infiltration. In conclusion,
       non-tuberculous mycobacteria can be easily disseminated in patients with
       AIDS because of dysfunction of cellular immunity, even when their
       primary lesions are not severe.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  AIDS-Related
       Opportunistic Infections/*COMPLICATIONS  Case Report  English Abstract
       Human  HIV-1  Male  Mycobacterium avium-intracellulare
       Infection/COMPLICATIONS  Mycobacterium Infections,
       Atypical/*COMPLICATIONS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).