Document 0911
 DOCN  M9440911
 TI    Transmission routes of HTLV-I: an analysis of 66 families.
 DT    9404
 AU    Take H; Umemoto M; Kusuhara K; Kuraya K; Department of Pediatrics,
       Kagoshima City Hospital.
 SO    Jpn J Cancer Res. 1993 Dec;84(12):1265-7. Unique Identifier : AIDSLINE
       MED/94124272
 AB    HTLV-I transmission routes were found for 66 carrier pregnant women by
       studying sera, from the carrier pregnant women, their mothers, and their
       husbands, and by obtaining detailed family histories at interview.
       Forty-one cases (62.1%) were considered to be instances of vertical
       transmission, 15 (22.8%) of sexual transmission, 6 (9.1%) of blood
       transfusion, and 4 (6.1%) undecided. To date, most cases of adult T-cell
       leukemia (ATL) have been considered to result from vertical
       transmission. Our results therefore imply that about 30% (22.8% + 9.1%)
       of the carrier pregnant women are at minimal risk of ATL. Moreover, in
       case of presumed husband-to-wife transmission, more than half (6/11)
       were infected between one year and four years after marriage.
 DE    Adolescence  Adult  Aged  Carrier State/*MICROBIOLOGY  Female  Human
       HTLV-I/IMMUNOLOGY/*PATHOGENICITY  HTLV-I Antibodies/ANALYSIS  HTLV-I
       Infections/*TRANSMISSION  Male  Middle Age  Pregnancy  Sexually
       Transmitted Diseases/*MICROBIOLOGY  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

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