Document 0914
 DOCN  M9440914
 TI    Activation of the human immunodeficiency virus type 1 long terminal
       repeat by skin-sensitizing chemicals in transgenic mice.
 DT    9404
 AU    Morrey JD; Jackson MK; Bunch TD; Sidwell RW; Department of Animal, Dairy
       and Veterinary Sciences, Utah State; University, Logan 84322-5600.
 SO    Intervirology. 1993;36(2):65-71. Unique Identifier : AIDSLINE
       MED/94124227
 AB    Topical dinitrochlorobenzene (DNCB) is often used for evaluating contact
       skin hypersensitivity in immunocompromised patients. We have determined,
       in this study, that topical application of DNCB alone, even without
       induction of contact skin hypersensitivity, was sufficient to observe
       activation of the human immunodeficiency virus promoter (long terminal
       repeat) in the skin of an HIV-1 long terminal repeat-luciferase
       transgenic mouse model. Such treatment might be contra-indicative in
       patients infected with the human immunodeficiency virus, because in
       earlier studies DNCB-exposed skin dendritic cells might migrate into
       draining lymph nodes which play an important role in AIDS pathogenesis.
 DE    Animal  Chemiluminescence  Dermatitis, Contact/METABOLISM
       Dinitrochlorobenzene/*PHARMACOLOGY  Dinitrofluorobenzene/PHARMACOLOGY
       Disease Models, Animal  Female  Gene Expression Regulation, Viral/*DRUG
       EFFECTS  HIV Long Terminal Repeat/*DRUG EFFECTS  Male  Mice  Mice,
       Transgenic  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       JOURNAL ARTICLE

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