Document 0934
 DOCN  M9440934
 TI    The pathogenesis of murine retroviral infection of the central nervous
       system.
 DT    9404
 AU    Wiley CA; Gardner M; Department of Pathology, University of California,
       San Diego, La; Jolla 92093-0612.
 SO    Brain Pathol. 1993 Apr;3(2):123-8. Unique Identifier : AIDSLINE
       MED/94122969
 AB    Several decades have lapsed since the original description of retroviral
       infection of the central nervous system (CNS) appeared. With the recent
       arrival of the autoimmune deficiency syndrome (AIDS) epidemic and the
       associated human retroviral encephalitis, interest in murine models has
       been rekindled. In most of the published studies, susceptible mouse
       strains are infected as neonates with molecularly cloned type-C
       retroviruses. In most models, a spongiform encephalopathy follows an
       early CNS endothelial cell infection. The subsequent pathogenesis of
       this encephalopathy is unknown. In some models neuronal and glial
       infection is seen, while in others only non-neuroglial elements are
       infected. This variation can be traced to differences in strains of mice
       and viruses in addition to differences in assays. The different models
       offer fertile experimental ground to decipher the role of direct versus
       indirect neuroglial damage. Reconciliation of these various models where
       the final neuropathology appears so similar, may be the key to
       understanding their pathogenesis.
 DE    Animal  Central Nervous System Diseases/*PATHOLOGY  Disease Models,
       Animal  Mice  National Institutes of Health (U.S.)  Retroviridae
       Infections/*PATHOLOGY  United States  CONSENSUS DEVELOPMENT CONFERENCE
       CONSENSUS DEVELOPMENT CONFERENCE, NIH  JOURNAL ARTICLE  REVIEW

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).