Document 0937
 DOCN  M9440937
 TI    Neurotropism of human immunodeficiency virus.
 DT    9404
 AU    Chiodi F; Fenyo EM; Department of Virology, Karolinska Institute,
       Stockholm, Sweden.
 SO    Brain Pathol. 1991 Apr;1(3):185-91. Unique Identifier : AIDSLINE
       MED/94122950
 AB    Three major characteristics of human immunodeficiency virus (HIV)
       infection define HIV as neurotropic. 1) Clinically, distinct
       neurological syndromes are associated with HIV infection and 2) presence
       of the virus as well as 3) pathological changes can be demonstrated in
       the central nervous system. Spread of HIV to the brain seems to be the
       general rule. Virus expression appears to be restricted during the
       asymptomatic period but increases with severity of HIV infection.
       Whether this reflects the emergence of virus variants with increased
       replicative capacity in brain cells has yet to be elucidated.
 DE    Animal  AIDS Dementia Complex/*MICROBIOLOGY/PATHOLOGY
       Brain/MICROBIOLOGY  Cerebrospinal Fluid/MICROBIOLOGY  Disease
       Susceptibility  Encephalitis/MICROBIOLOGY/PATHOLOGY  Glioma/PATHOLOGY
       Haplorhini  Human  HIV/ISOLATION & PURIF/PHYSIOLOGY/*PATHOGENICITY
       Neuroblastoma/PATHOLOGY  Neurons/*MICROBIOLOGY  Organ Specificity
       Retroviridae Infections/MICROBIOLOGY/PATHOLOGY  Simian Acquired
       Immunodeficiency Syndrome/PATHOLOGY  Support, Non-U.S. Gov't  Tumor
       Cells, Cultured  Virus Replication  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

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