Document 0938
 DOCN  M9440938
 TI    Immunopathogenesis of HIV encephalitis.
 DT    9404
 AU    Achim CL; Schrier RD; Wiley CA; Department of Pathology, University of
       California San Diego, La; Jolla 92093-0612.
 SO    Brain Pathol. 1991 Apr;1(3):177-84. Unique Identifier : AIDSLINE
       MED/94122949
 AB    HIV infection leads to severe immunosuppression and in a sub-population
       of patients, encephalitis. Whether systemic immunosuppression is
       required for CNS infection is still unclear. However, latent infection
       of monocytes/macrophages is an important mechanism by which HIV escapes
       immune surveillance and enters the CNS. Unlike other viral
       encephalitides, HIV predominantly infects macrophages/microglia and not
       neurons and glia. These cells produce retroviral proteins and cytokines
       which may be neurotoxic. Despite significant MHC expression within the
       CNS, there is a limited infiltration of immune cells, possibly due to a
       defect in systemic immunity. Anti-retroviral therapy by decreasing viral
       replication and reversing immunosuppression, may arrest nervous system
       damage.
 DE    Cell Movement  Central Nervous System/IMMUNOLOGY/MICROBIOLOGY
       Cytopathogenic Effect, Viral
       Encephalitis/IMMUNOLOGY/*MICROBIOLOGY/PATHOLOGY  Human  HIV
       Infections/IMMUNOLOGY/*PATHOLOGY  Immunocompromised Host
       Macrophages/MICROBIOLOGY  Meningitis, Aseptic/IMMUNOLOGY/MICROBIOLOGY
       Monocytes/MICROBIOLOGY  Papovaviridae Infections/IMMUNOLOGY
       Poliomyelitis/IMMUNOLOGY  Polyomavirus hominis 2  Tumor Virus
       Infections/IMMUNOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).