Document 0939
 DOCN  M9440939
 TI    Neuropathology of human immunodeficiency virus infection.
 DT    9404
 AU    Budka H; Neurological Institute, University of Vienna, Wien, Austria.
 SO    Brain Pathol. 1991 Apr;1(3):163-75. Unique Identifier : AIDSLINE
       MED/94122948
 AB    Neuropathology has defined novel HIV-specific diseases at tissue level:
       HIV encephalitis and HIV leukoencephalopathy. Both occur usually in the
       later stages of the AIDS infection and consistently demonstrate large
       amounts of HIV products. In contrast to this HIV-specific
       neuropathology, HIV-associated neuropathology features unspecific
       syndromes with disputed relation to HIV infection: myelin pallor,
       vacuolar myelopathy, vacuolar leukoencephalopathy, lymphocytic
       meningitis, and diffuse poliodystrophy. All types of neuropathology may
       contribute to clinical manifestation according to severity, extent, and
       distribution of lesions, but clinico-pathologic correlation may be poor
       in the individual case. Neuropathologic and other data suggest two major
       pathogenetic pathways of HIV-associated CNS damage: First, systemic and
       local increase of the virus load leads to HIV encephalitis or HIV
       leukoencephalopathy; this is corroborated by prominent HIV production
       within such lesions. Second, neuronotoxicity by HIV proteins or factors
       secreted from infected cells is supported by histological changes of
       diffuse poliodystrophy and by morphometric loss of frontocortical
       neurons.
 DE    AIDS Dementia Complex/MICROBIOLOGY/*PATHOLOGY
       Encephalitis/*MICROBIOLOGY/PATHOLOGY  Human  HIV/ISOLATION & PURIF  HIV
       Infections/MICROBIOLOGY/*PATHOLOGY  Meningitis,
       Aseptic/MICROBIOLOGY/PATHOLOGY  Neurons/PATHOLOGY  Support, Non-U.S.
       Gov't  Vacuoles  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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