Document 0940 DOCN M9440940 TI AIDS dementia complex and HIV-1 infection: a view from the clinic. DT 9404 AU Price RW; Sidtis JJ; Brew BJ; Department of Neurology, University of Minnesota, Minneapolis; 55455-0323. SO Brain Pathol. 1991 Apr;1(3):155-62. Unique Identifier : AIDSLINE MED/94122947 AB The AIDS dementia complex (ADC) is a clinical syndrome which characteristically presents as a subcortical dementia with cognitive, motor and behavioral changes. While the pathogenesis remains puzzling in a number of critical aspects, ADC likely relates in a fundamental way to HIV-1, itself, rather than to a secondary, opportunistic condition. This review focuses on some of the clinical information which bears on the pathogenesis of this syndrome and its relation to HIV-1 infection. This information derives from studies of the clinical character of ADC, its epidemiology and natural history, cerebrospinal fluid analysis, neuroimaging results, clinical correlates of pathological findings and its response to antiviral therapy. DE Antiviral Agents/THERAPEUTIC USE *AIDS Dementia Complex/CEREBROSPINAL FLUID/DRUG THERAPY/ EPIDEMIOLOGY/ETIOLOGY/PATHOLOGY/PSYCHOLOGY Human *HIV-1 Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).