Document 0945
 DOCN  M9440945
 TI    [Association of rheumatoid arthritis and Kaposi disease. Apropos of a
       case arising after intraarticular corticotherapy]
 DT    9404
 AU    Azais I; Lambert de Cursay G; Deblais F; Deschamps O; Gandon P; Alcalay
       M; Bontoux D; Service de Rhumatologie, CHRU Poitiers.
 SO    Rev Rhum Ed Fr. 1993 Mar;60(3):240-4. Unique Identifier : AIDSLINE
       MED/94122721
 AB    A 66 year old Corsican HLA A2 and DR5-positive male with moderately
       active seropositive destructive rheumatoid arthritis developed Kaposi's
       sarcoma after intraarticular administration of corticosteroids. He had
       no history of oral corticosteroid therapy, organ transplantation, AIDS,
       or cancer. Chlorambucil proved ineffective but the outcome was
       spontaneously favorable following discontinuation of oral corticosteroid
       therapy initiated after the development of the skin lesions. Six
       previous reports of concomitant rheumatoid arthritis and Kaposi's
       sarcoma were found. All six cases occurred following systemic
       corticosteroid therapy. The high incidence of rheumatoid arthritis and
       the small number of patients with rheumatoid arthritis and Kaposi's
       sarcoma suggest that concomitant occurrence of the two conditions may be
       fortuitous. However, the responsibility of corticosteroid therapy, which
       preceded development of Kaposi's sarcoma in every case, cannot be ruled
       out.
 DE    Aged  Arthritis, Rheumatoid/*COMPLICATIONS/DRUG THERAPY/IMMUNOLOGY  Case
       Report  Chlorambucil/THERAPEUTIC USE  English Abstract  Human  Immunity
       Injections, Intra-Articular/ADVERSE EFFECTS  Male
       Prednisolone/ADMINISTRATION & DOSAGE/*ADVERSE EFFECTS  Sarcoma,
       Kaposi's/*CHEMICALLY INDUCED  Xeroderma Pigmentosum/DRUG
       THERAPY/*ETIOLOGY/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).