Document 0946
 DOCN  M9440946
 TI    Genes encoding antigenic surface glycoproteins in Pneumocystis from
       humans.
 DT    9404
 AU    Stringer SL; Garbe T; Sunkin SM; Stringer JR; Department of Molecular
       Genetics, Biochemistry, and Microbiology,; University of Cincinnati,
       College of Medicine, Ohio 45267.
 SO    J Eukaryot Microbiol. 1993 Nov-Dec;40(6):821-6. Unique Identifier :
       AIDSLINE MED/94122711
 AB    Pneumocystis is a eukaryotic microbe that causes pneumocystosis, an
       AIDS-associated pneumonia. Pneumocystosis also occurs in many other
       mammalian species, and animal-derived organisms have been extensively
       utilized in Pneumocystis research. Pneumocystis from diverse hosts
       contain a large glycoprotein (gpA/MSG) on the surface. Antibodies
       elicited against gpA/MSG of Pneumocystis from humans sometimes
       cross-react with epitopes on proteins of similar size from Pneumocystis
       from other host species. Here we report the isolation and partial
       sequence of two presumptive gpA/MSG genes from human-derived
       Pneumocystis. The cloned human-derived Pneumocystis gpA/MSG genes and
       predicted peptides were different from those previously isolated from
       Pneumocystis from rats and ferrets. The genome of human-derived
       Pneumocystis contained multiple copies of sequences related to the two
       cloned gpA/MSG genes.
 DE    Amino Acid Sequence  Animal  Antigens, Fungal/*GENETICS  AIDS-Related
       Opportunistic Infections/MICROBIOLOGY  Base Sequence  Cloning, Molecular
       Comparative Study  DNA, Fungal/ANALYSIS  *Genes, Fungal  Human
       Lung/MICROBIOLOGY  Membrane Glycoproteins/*GENETICS  Molecular Sequence
       Data  Pneumocystis carinii/*GENETICS/IMMUNOLOGY/ISOLATION & PURIF
       Pneumocystis carinii Infections/ETIOLOGY/MICROBIOLOGY  Rats  Rats,
       Inbred BN  Sequence Homology, Amino Acid  Sequence Homology, Nucleic
       Acid  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).