Document 0952
 DOCN  M9440952
 TI    Infectious AIDS--stretching the germ theory beyond its limits.
 DT    9404
 AU    Duesberg P; Department of Molecular and Cell Biology, University of;
       California, Berkeley 94720.
 SO    Int Arch Allergy Immunol. 1994;103(2):118-27. Unique Identifier :
       AIDSLINE MED/94122536
 AB    The hypothesis that human immunodeficiency virus (HIV) causes AIDS was
       advanced in 1984, based only on circumstantial evidence. To this date,
       the primary evidence are correlations between the presence of antibody
       against HIV and AIDS. But these correlations are biased by proponents of
       the HIV hypothesis in favour of HIV. They ignore HIV-free AIDS and they
       base correlations on selected studies because there are no national
       HIV-AIDS statistics. The HIV-AIDS hypothesis has made the following
       predictions: (1) AIDS would 'explode' from the original risk groups into
       the general population via sexual transmission of HIV. (2) Health care
       workers would contract AIDS from their patients, scientists from
       propagating HIV, and prostitutes from their clients. (3) The 150
       chimpanzees that have been experimentally inoculated with HIV, and the
       15,000 American hemophiliacs who have been iatrogenically inoculated
       before 1984, would develop AIDS. (4) Antiviral immunity and vaccines
       would protect against AIDS. (5) HIV would cause AIDS by killing T-cells.
       (6) AIDS would occur only in people infected by HIV. But none of these
       predictions proved to be correct. Recent studies show that HIV is a
       passenger virus instead of the cause of AIDS: (1) AIDS occurs at
       unpredictable intervals after infection; (2) HIV may be active, passive,
       or totally absent from otherwise identical AIDS cases. Indeed, AIDS does
       not meet one of the classical criteria of infectious disease: (1) Equal
       distribution between the sexes; (2) disease following infection within
       days or weeks, the time microbes take to become either immunogenic or
       pathogenic or both; (3) the presence of a common active microbe.
       Therefore it is proposed that American and European AIDS is caused by
       the long-term consumption of recreational drugs and the anti-HIV drug
       AZT. This hypothesis is testable and provides a rational basis for AIDS
       control.
 DE    Acquired Immunodeficiency Syndrome/ETIOLOGY/*IMMUNOLOGY  Antibody
       Diversity/*IMMUNOLOGY  AIDS Vaccines/IMMUNOLOGY  Female  Human  HIV
       Infections/COMPLICATIONS/*IMMUNOLOGY
       HIV-1/*IMMUNOLOGY/PHYSIOLOGY/PATHOGENICITY  Male  Substance
       Abuse/COMPLICATIONS  Support, Non-U.S. Gov't  Zidovudine/ADVERSE EFFECTS
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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