Document 0953
 DOCN  M9440953
 TI    HIV and complement: role of the complement system in HIV infection.
 DT    9404
 AU    Marschang P; Ebenbichler CF; Dierich MP; Institut fur Hygiene,
       Innsbruck, Austria.
 SO    Int Arch Allergy Immunol. 1994;103(2):113-7. Unique Identifier :
       AIDSLINE MED/94122535
 AB    HIV, in contrast to animal retroviruses, is not lysed by human serum but
       nevertheless the virus as well as virus-infected cells activate the
       complement system efficiently. HIV activates the classical pathway by
       binding C1q to the transmembrane protein gp41. On the surface of
       HIV-infected cells, both the alternative and the classical pathway are
       activated. Complement-treated HIV has an enhanced ability to infect
       cells carrying receptors for C3 fragments. By this mechanism complement
       can target the virus to certain cells, e.g. follicular dendritic cells.
       HIV-infected complement-coated cells can interact with complement
       receptor carrying cells and thereby spread the infection or cause the
       destruction of the infected cells. Due to direct or indirect effects of
       HIV the complement system is in an activated state and the cellular
       expression of complement receptors as well as regulatory molecules is
       modified in the blood of HIV-infected patients.
 DE    Animal  Cell Adhesion  Complement Activation/IMMUNOLOGY  Complement
       Pathway, Classical/IMMUNOLOGY  Complement 1q/*IMMUNOLOGY/METABOLISM
       Human  HIV Envelope Protein gp41/METABOLISM  HIV Infections/*IMMUNOLOGY
       HIV-1/*IMMUNOLOGY  Receptors, Complement/IMMUNOLOGY  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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