Document 0954
 DOCN  M9440954
 TI    Intrathecal synthesis of beta 2-microglobulin and lysozyme: differential
       markers of nervous system involvement in patients infected with human
       immunodeficiency virus type 1.
 DT    9404
 AU    Meillet D; Belec L; Celton N; Gervais A; Reboul J; Gentilini M; Delattre
       J; Schuller E; Laboratoire de Biochimie, Hopital de la Salpetriere,
       Paris,; France.
 SO    Eur J Clin Chem Clin Biochem. 1993 Oct;31(10):609-15. Unique Identifier
       : AIDSLINE MED/94122248
 AB    beta 2-Microglobulin and lysozyme were determined in paired serum and
       cerebrospinal fluid samples from 137 patients, using immunofluorometry
       and ELISA, respectively. Of these patients, 54 were infected by human
       immunodeficiency virus type 1 (HIV1) (including 20 AIDS dementia
       patients), 73 were HIV1-seronegative with neurological diseases
       (meningitis (n = 10), multiple sclerosis (n = 29), other neurological
       diseases (n = 34)) and 10 were controls. Intrathecal synthesis of beta
       2-microglobulin occurred in each group. Conversely, lysozyme intrathecal
       synthesis was found only in meningitis (10/10) and in HIV1-infection
       (24/54). A pathological increase in beta 2-microglobulin intrathecal
       synthesis (> or = 2 mg/l) was observed in 45 patients (34 HIV1-infected
       patients and 11 HIV1-seronegative patients with neurological diseases).
       Serum concentration and intrathecal synthesis of beta 2-microglobulin
       were correlated only in the 20 AIDS dementia patients. The cerebrospinal
       fluid beta 2-microglobulin and lysozyme concentrations were correlated
       in the 54 HIV1-infected patients only. Blood CD4 + T-cell count was
       correlated negatively with beta 2-microglobulin intrathecal synthesis
       but not with lysozyme intrathecal synthesis. These data suggest that in
       the absence of any central nervous system opportunistic process the
       increase of beta 2-microglobulin intrathecal synthesis (> or = 2 mg/l)
       may be a reliable marker of central nervous system involvement in
       HIV1-infected patients. Intrathecal synthesis of lysozyme was related
       principally to HIV1-encephalitis and central nervous system
       opportunistic processes.
 DE    beta 2-Microglobulin/*BIOSYNTHESIS/CEREBROSPINAL FLUID  Adult
       Albumins/METABOLISM  AIDS Dementia Complex/*METABOLISM  Biological
       Markers/BLOOD/CEREBROSPINAL FLUID  Central Nervous System
       Diseases/*METABOLISM  Complement 4/METABOLISM  Female  Human  HIV
       Infections/*METABOLISM/PHYSIOPATHOLOGY  *HIV-1
       Immunoglobulins/METABOLISM  Male  Middle Age
       Muramidase/*BIOSYNTHESIS/BLOOD/CEREBROSPINAL FLUID  Predictive Value of
       Tests  Spinal Cord/*METABOLISM  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).