Document 0001
 DOCN  M9460001
 TI    Studies on lipoate effects on blood redox state in human
       immunodeficiency virus infected patients.
 DT    9404
 AU    Fuchs J; Schofer H; Milbradt R; Freisleben HJ; Buhl R; Siems W; Grune T;
       Department of Dermatology, University Hospital, Frankfurt/Main,; Fed.
       Rep. of Germany.
 SO    Arzneimittelforschung. 1993 Dec;43(12):1359-62. Unique Identifier :
       AIDSLINE MED/94190328
 AB    Several investigators have implicated that human immunodeficiency virus
       (HIV) infected patients have a compromised antioxidant defense system.
       Blood antioxidants are decreased and peroxidation products of lipids and
       proteins are increased in the patients. This may have pathophysiological
       implications, because antioxidants, such as glutathione, and reactive
       oxidants are involved in the regulation of the human immunodeficiency
       virus. Consequently it was suggested that HIV infected patients may
       benefit from antioxidant supplementation therapy. In a open and
       unblinded pilot study the short term effect of the natural antioxidant
       lipoate (Thioctacid) on blood antioxidants and peroxidation products was
       investigated in HIV positive patients (CDC IV). In the majority of the
       patients, lipoate increased plasma ascorbate (9 of 10 patients) total
       glutathione (7 of 7 patients), total plasma thiol groups (8 of 9
       patients); T helper lymphocytes and T helper/suppressor cell ratio (6 of
       10 patients), while the lipid peroxidation products malondialdehyde (8
       of 9 patients) and 4-hydroxynonenal (7 of 9 patients) were decreased.
       The results of this pilot study indicate that lipoate supplementation
       changes the blood redox state of HIV infected patients. A prospective
       and longitudinal therapy study is warranted to investigate the long term
       effects of lipoate therapy on blood redox state, disease progression and
       incidence of opportunistic infections in HIV infected patients.
 DE    Adult  Antioxidants/*PHARMACOLOGY  Human  HIV Infections/*BLOOD  HIV
       Seropositivity  Lipid Peroxidation/DRUG EFFECTS  Male
       Malondialdehyde/BLOOD  Oxidation-Reduction  Pilot Projects  Thioctic
       Acid/*PHARMACOLOGY  CLINICAL TRIAL  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).