Document 0004
 DOCN  M9460004
 TI    Immune system-central nervous system interactions: effect and
       immunomodulatory consequences of immune system mediators on the brain.
 DT    9404
 AU    Black PH; Department of Microbiology, Boston University School of
       Medicine,; Massachusetts 02118.
 SO    Antimicrob Agents Chemother. 1994 Jan;38(1):7-12. Unique Identifier :
       AIDSLINE MED/94190055
 AB    A bidirectional circuit exists between the central nervous system and
       the immune system, since activation of the immune system results in the
       elaboration of cytokines and inflammatory mediators; these mediators
       induce hypothalamic CRF, which stimulates the release of the same
       immunosuppressive molecules that mediate the response to stress. The
       brain, therefore, is likely to be involved in immune system regulation.
       Hypofunctioning of the HPA axis with insufficient down regulation may be
       involved in autoimmune or other diseases with excessive immune system
       activation. Hyperfunctioning of the HPA axis, which is not appropriately
       suppressed, has been found in a large number of patients with major
       depression. Evidence that stress is an important factor in both lowering
       resistance to infectious agents and contributing to the reactivation of
       latent viruses is discussed. Also discussed is the evidence that stress
       induces proinflammatory cytokines which may contribute to both the
       pathogenesis of inflammatory diseases of unknown etiology and the
       progression of HIV infection to AIDS by activation of HIV replication.
 DE    Adjuvants, Immunologic/*PHYSIOLOGY  Animal  Brain/*PHYSIOLOGY  Central
       Nervous System/*IMMUNOLOGY  Cytokines/PHYSIOLOGY  Human  Immune
       System/*IMMUNOLOGY  Stress, Psychological/IMMUNOLOGY  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

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       protected by Copyright Law (Title 17, U.S.Code).