Document 0016
 DOCN  M9460016
 TI    [Prevalence of rheumatic manifestations in human immunodeficiency virus
       infection]
 DT    9404
 AU    Rogeaux O; Fassin D; Gentilini M; Departement des Maladies Infectieuses
       et Tropicales, Groupe; Hospitalier Pitie-Salpetriere, Paris.
 SO    Ann Med Interne (Paris). 1993;144(7):443-8. Unique Identifier : AIDSLINE
       MED/94189972
 AB    Various rheumatic manifestations have been reported in HIV infected
       patients, but the prevalence of these manifestations is not well known.
       Therefore, we have designed a prospective study to define the rheumatic
       manifestations in those patients. METHODS: 121 patients (stage IV of CDC
       classification) were assessed by physical examination and biological
       tests. RESULTS: arthralgia was found in 12.4%; painful articular
       syndrome occurred in 4.1%; arthritis was present in 6.6%; out of 8 cases
       of arthritis, only 2 had spondylarthropathy. The articular
       manifestations were mostly oligo- or polyarticular, rarely invalidating,
       sometimes recurrent. No septic arthritis, no myositis and only 1 case of
       vasculitis was found. Raynaud's phenomenon prevalence was 17.4%, 43% of
       which appeared after HIV seropositivity was known. Lacrymal
       hyposecretion assessed by Schirmer's test was found in 49.6%. However,
       this did not prove the existence of a Sjogren's syndrome as no
       histological examination was performed. Back pain reached 38.6%. Sciatic
       neuralgias were noted in 17.6%. Biological and immunological results
       were unspecific. Low levels of antinuclear antibodies were found in
       11.1% cases. They were more frequently found when articular
       manifestations existed. A higher level of CD8 lymphocytes was also noted
       when articular manifestations were present. No statistical link existed
       between the different rheumatic manifestations. CONCLUSION: our results
       show that the prevalence of rheumatic manifestations in HIV infection is
       slightly increased (24.7%). This study is the first to emphasize the
       frequency of Raynaud's phenomenon and lacrymal hyposecretion in HIV
       patients.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  English
       Abstract  Female  Human  HIV Infections/*COMPLICATIONS  Male  Prevalence
       Prospective Studies  Retrospective Studies  Rheumatic
       Diseases/EPIDEMIOLOGY/*ETIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

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