Document 0019
 DOCN  M9460019
 TI    Localized cerebral proton MR spectroscopy in HIV infection and AIDS.
 DT    9404
 AU    Chong WK; Paley M; Wilkinson ID; Hall-Craggs MA; Sweeney B; Harrison MJ;
       Miller RF; Kendall BE; MR Unit, Middlesex Hospital, London, England.
 SO    AJNR Am J Neuroradiol. 1994 Jan;15(1):21-5. Unique Identifier : AIDSLINE
       MED/94189467
 AB    PURPOSE: To document differences in the cerebral proton MR spectra of
       patients with early and late stages of human immunodeficiency virus
       (HIV) infection. METHOD: We studied the relative N-acetyl-aspartate
       (NAA) levels by localized proton spectroscopy of the parietooccipital
       region of the brain in 43 HIV-seropositive patients, including 26 with
       an acquired immunodeficiency syndrome (AIDS)-defining diagnosis, and in
       eight control subjects. RESULTS: Reduced relative NAA levels were shown
       in those HIV-1-seropositive patients: 1) with AIDS against
       HIV-1-seropositive patients without AIDS (P < .04); 2) with
       HIV-1-associated cognitive/motor complex against neurologically healthy
       patients (P < .007); 3) with encephalopathic changes on MR against those
       with normal imaging (P < .001); and 4) on follow-up against their
       results on initial study (P < .03). CONCLUSIONS: By clinical (Centers
       for Disease Control classification) and radiologic (MR evidence of
       white-matter disease) criteria indicating late-stage HIV infection,
       reduced relative levels of NAA have been demonstrated. Spectroscopic
       abnormalities can be quantitatively tracked with time. This paper
       demonstrates the clinical use of detecting NAA as a putative in vivo
       measure of the neuronal loss that has been demonstrated in postmortem
       studies of patients with AIDS. This neuronal loss, which is believed to
       underlie the HIV-1-associated cognitive/motor complex, is thought to be
       attributable directly or indirectly to the presence of HIV in the brain.
       Proton spectroscopy may serve as a quantitative noninvasive indicator of
       this aspect of cerebral involvement in HIV disease.
 DE    Acquired Immunodeficiency Syndrome/*METABOLISM  Adult  Aspartic
       Acid/ANALOGS & DERIVATIVES/ANALYSIS  AIDS Dementia Complex/METABOLISM
       AIDS-Related Complex/METABOLISM  *Brain Chemistry  Choline/ANALYSIS
       Creatine/ANALYSIS  Diagnosis, Differential  Human  HIV
       Seropositivity/*METABOLISM  Middle Age  *Nuclear Magnetic Resonance
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).