Document 0047
 DOCN  M9460047
 TI    A screening test for subtle cognitive impairment early in the course of
       HIV infection.
 DT    9404
 AU    Mcmanis SE; Brown GR; Zachary R; Rundell JR; Department of Psychiatry,
       Wilford Hall Medical Center.
 SO    Psychosomatics. 1993 Sep-Oct;34(5):424-31. Unique Identifier : AIDSLINE
       MED/94188456
 AB    The authors report on the use of the Rey-Osterrieth Complex Figure Copy
       (ROC) and Memory (ROM) test as a bedside screening measure of cognitive
       impairment in 67 HIV-seropositive persons (43 men, 24 women).
       HIV-seropositive individuals scored significantly worse than 49
       HIV-seronegative matched individuals (33 men, 16 women) in the control
       group on the ROC (P = 0.045, effect size = 0.39), but not on the ROM
       test. The scores did not correlate with stage of HIV infection, CD4a
       cell counts, cerebrospinal fluid parameters, or measures of affective
       state. No gender effects on performance were noted. It is concluded that
       while cognitive deficits may occur early in asymptomatic HIV disease,
       the ROC/ROM test as the authors used it is not a useful screening tool
       for clinicians. The study also suggests that the growing number of
       HIV-positive women should be included in neuropsychological studies of
       early HIV disease.
 DE    Adolescence  Adult  Cognition Disorders/DIAGNOSIS/*ETIOLOGY  Comparative
       Study  Female  Human  HIV Seropositivity/*PSYCHOLOGY  Male  Psychiatric
       Status Rating Scales  Task Performance and Analysis  JOURNAL ARTICLE

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