Document 0065
 DOCN  M9460065
 TI    Major aphthous ulcers in patients with HIV disease.
 DT    9404
 AU    Muzyka BC; Glick M; Temple University School of Dentistry, Philadelphia,
       Pa.
 SO    Oral Surg Oral Med Oral Pathol. 1994 Feb;77(2):116-20. Unique Identifier
       : AIDSLINE MED/94188036
 AB    Major aphthous ulcers are associated with a high degree of morbidity in
       patients infected with human immunodeficiency virus. A large
       representative cohort infected with human immunodeficiency virus was
       examined to evaluate the prevalence of major aphthous ulcers,
       demographic data of patients with major aphthous ulcers, and the usage
       of major aphthous ulcers as a marker for immune deterioration. The
       effects of tobacco smoking and the use of specific antibiotics,
       trimethoprim/sulfamethoxazole or dapsone, on the development of major
       aphthous ulcers was also investigated. In a population of 767 persons
       infected with human immunodeficiency virus, major aphthous ulcers were
       found at a prevalence rate of 3.1% (24 patients). This type of lesion
       did not show any predilection for human immunodeficiency virus
       transmission category, ethnic group, or gender. Persons who received
       trimethoprim/sulfamethoxazole or dapsone or had a history of tobacco
       smoking showed a decreased prevalence of major aphthous ulcers. All
       patients (100%) with major aphthous ulcers had CD4+ cell counts below
       100 cells/mm3, but only 50% had a previous acquired immunodeficiency
       syndrome defining illness. Major aphthous ulcers in persons infected
       with human immunodeficiency virus are suggestive of severe immune
       suppression and may serve as a marker for human immunodeficiency virus
       disease progression.
 DE    Adult  Biological Markers  CD4-CD8 Ratio  Dapsone/THERAPEUTIC USE
       Ethnic Groups  Female  Human  HIV Infections/*COMPLICATIONS  Immune
       Tolerance  Male  Pennsylvania/EPIDEMIOLOGY  Prevalence  Prospective
       Studies  Risk Factors  Smoking  Stomatitis, Aphthous/DRUG
       THERAPY/EPIDEMIOLOGY/*ETIOLOGY/  IMMUNOLOGY
       Sulfamethoxazole/THERAPEUTIC USE  Trimethoprim/THERAPEUTIC USE  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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