Document 0067
 DOCN  M9460067
 TI    [Survival of patients following the diagnosis of AIDS in the Amsterdam
       region, 1982-1991]
 DT    9404
 AU    Bindels PJ; Krol A; Mulder-Folkerts DK; van den Hoek JA; Coutinho RA;
       GG&GD, sector Volksgezondheid en Milieu, Amsterdam.
 SO    Ned Tijdschr Geneeskd. 1994 Mar 5;138(10):513-8. Unique Identifier :
       AIDSLINE MED/94187907
 AB    OBJECTIVE. To evaluate the survival of 975 AIDS patients diagnosed in
       the Amsterdam region between 1982 and 1991, with follow-up until
       December 31st, 1992. METHODS. Analysis of data from the active AIDS
       surveillance system for the Amsterdam region at the Municipal Health
       Service. RESULTS. Amsterdam region residents had 1, 2 and 3-year
       survivals of 69.8%, 42.6% and 21.2%, respectively. The 5-year survival
       was 7.7%. The median survival probability for all patients showed great
       improvement, from 9 months in 1982-1985 to 26 months in 1990. For
       patients initially presenting with only Pneumocystis carinii pneumonia
       (PCP) the greatest improvement occurred between the period 1982-1985 and
       the year 1986. For patients without PCP the most important improvement
       occurred one year later. From 1988 onwards no important improvement in
       the 1-year survival is noticed. The 2-year survival, however, appears
       still to be increasing. In a Cox proportional hazards model the
       following variables were found to be independent predictors for
       survival: age at diagnosis, earliest clinical AIDS manifestations, year
       of diagnosis and HIV risk group. No differences were seen in the 1 and
       2-year survival probabilities for men and women with AIDS. Heterosexual
       men and women tended to have a poorer survival than intravenous drug
       users and homosexual and bisexual men. CONCLUSION. A noticeable
       improvement in the survival probability with time occurred for AIDS
       patients living in the Amsterdam region through the years 1982-1991,
       although the overall survival after AIDS diagnosis is still poor. The
       1-year survival appears to have reached a plateau, the 2-year survival
       is still increasing. Improved clinical experience, awareness of HIV
       related complaints in high risk groups, better diagnostic methods and
       the availability of proper medication (prophylactic and treatment) are
       the most likely explanations of the improvement in survival.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*MORTALITY  Adult
       AIDS-Related Opportunistic Infections/COMPLICATIONS/MORTALITY  English
       Abstract  Female  Human  Male  Middle Age  Netherlands/EPIDEMIOLOGY
       Pneumonia, Pneumocystis carinii/COMPLICATIONS/MORTALITY  Risk Factors
       Sex Factors  Survival Analysis  JOURNAL ARTICLE

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