Document 0084
 DOCN  M9460084
 TI    [Adult T cell leukemia with cytomegalovirus associated hemophagocytic
       syndrome]
 DT    9404
 AU    Shirono K; Hirai N; Inada T; Tsuda H; Ishihara A; Miyayama H; Division
       of Clinical Hematology and Immunology, Kumamoto City; Hospital.
 SO    Rinsho Ketsueki. 1994 Feb;35(2):177-82. Unique Identifier : AIDSLINE
       MED/94187192
 AB    A 59-year-old woman, diagnosed as adult T-cell leukemia (ATL), was
       admitted because of fever and disturbance of consciousness. Peripheral
       blood examination demonstrated leukopenia and anemia, and subsequently
       thrombocytopenia. Bone marrow aspiration showed the increase of mature
       histiocytes with hemophagocytosis and a diagnosis of hemophagocytic
       syndrome (HPS) was established. She died due to respiratory failure on
       the eighth hospital day. Autopsy histological examination revealed
       systemic cytomegalovirus (CMV) infection with CMV pneumonia, and also
       demonstrated the findings of HPS in bone marrow, lymph nodes, and
       spleen. This case was considered as virus associated hemophagocytic
       syndrome (VAHS) developed by CMV infection. CMV is one of the causative
       viruses of VAHS and the opportunistic infection. In the patient with ATL
       in the immunodeficiency state, VAHS accompanied with opportunistic
       infection might be one of the causes of pancytopenia.
 DE    Case Report  Cytomegalovirus Infections/*COMPLICATIONS  English Abstract
       Female  Histiocytosis, Non-Langerhans-Cell/*ETIOLOGY  Human
       Immunocompromised Host  Leukemia, T-Cell/*COMPLICATIONS  Middle Age
       Opportunistic Infections/*COMPLICATIONS  Pancytopenia/ETIOLOGY  JOURNAL
       ARTICLE

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