Document 0091
 DOCN  M9460091
 TI    Variability of the env gene in cynomolgus macaques persistently infected
       with human immunodeficiency virus type 2 strain ben.
 DT    9404
 AU    Tolle T; Petry H; Bachmann B; Hunsmann G; Luke W; Department of Virology
       and Immunology, German Primate Centre,; Gottingen.
 SO    J Virol. 1994 Apr;68(4):2765-71. Unique Identifier : AIDSLINE
       MED/94187122
 AB    The sequence variability of distinct regions of the proviral env gene of
       human immunodeficiency virus type 2 strain ben (HIV-2ben) isolated
       sequentially over 3 to 4 years from six experimentally infected macaques
       was studied. The regions investigated were homologous to the V1, V2, V3,
       V4, V5, and V7 hypervariable regions identified in the env genes of
       HIV-1 and simian immunodeficiency virus SIVmac, respectively. In
       contrast to findings with HIV-1 and SIVmac, the V1- and V2-homologous
       regions were found to be highly conserved during the course of the
       HIV-2ben infection in macaques. The V3-homologous region showed a degree
       of variation comparable to that of HIV-1 but not of SIV. In the V4-,
       V5-, and V7-homologous regions, mutation hot spots were detected in most
       reisolates of the infected monkeys. Most of these mutations occurred
       during the first 10 weeks after infection. After 50 weeks, new mutations
       were rarely detected. At most mutation sites, a dynamic equilibrium
       between the mutated viral isotype and the infecting predominant wild
       type was present. This equilibrium might prevent an accumulation of
       mutations in isolates later in the course of infection.
 DE    Amino Acid Sequence  Animal  Base Sequence  Comparative Study  Conserved
       Sequence  Genes, env/*GENETICS  HIV Infections/*MICROBIOLOGY
       HIV-2/*GENETICS  Leukocytes, Mononuclear/MICROBIOLOGY  Lymph
       Nodes/MICROBIOLOGY  Macaca fascicularis/*MICROBIOLOGY  Molecular
       Sequence Data  Mutation  Proviruses/GENETICS  Sequence Homology, Amino
       Acid  Sequence Homology, Nucleic Acid  Time Factors  *Variation
       (Genetics)  JOURNAL ARTICLE

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