Document 0110
 DOCN  M9460110
 TI    Immunopathogenic events in acute infection of rhesus monkeys with simian
       immunodeficiency virus of macaques.
 DT    9404
 AU    Reimann KA; Tenner-Racz K; Racz P; Montefiori DC; Yasutomi Y; Lin W;
       Ransil BJ; Letvin NL; New England Regional Primate Research Center,
       Harvard Medical; School, Southborough, Massachusetts 01772.
 SO    J Virol. 1994 Apr;68(4):2362-70. Unique Identifier : AIDSLINE
       MED/94187077
 AB    Infection of the rhesus monkey with simian immunodeficiency virus of
       macaques (SIVmax) was employed to explore the early immune events
       associated with the initial containment of an acute AIDS virus
       infection. In nine rhesus monkeys infected intravenously with uncloned
       SIVmac strain 251, high-level p27 plasma antigenemia was usually
       detected transiently from approximately day 7 through day 21 following
       virus inoculation. SIVmac replication in lymph nodes measured by in situ
       RNA hybridization closely paralleled the time course and magnitude of
       viremia. The containment of SIVmac spread by 3 to 4 weeks following
       infection suggests an efficient, early immune control of this virus
       infection. Anti-SIVmac antibodies were first detected in the blood at
       approximately day 14. At the time antigenemia was decreased or cleared,
       SIVmac neutralizing antibodies were present. A rise in circulating and
       lymph node CD8+ T cells also occurred coincident with the clearance of
       antigenemia and persisted thereafter. These CD8+ lymphocytes in lymph
       nodes had increased expression of both major histocompatibility complex
       class II and the adhesion molecule LFA-1; they also demonstrated
       decreased expression of the naive T-cell-associated CD45RA molecule.
       SIVmac-specific cytotoxic T-lymphocyte precursors were detected in both
       blood and lymph node by 7 days post-virus inoculation. These studies
       indicate that both virus-specific humoral and cellular immune mechanisms
       in blood and lymph node are associated with the clearance of viremia
       that occurs within the first month of infection of rhesus monkeys with
       SIVmac.
 DE    Animal  Antibodies, Viral/BLOOD  Antigens, CD8/IMMUNOLOGY  Antigens,
       Viral/BLOOD  Gene Products, gag/BLOOD/IMMUNOLOGY  Immunophenotyping
       Lymph Nodes/*IMMUNOLOGY  Lymphocytosis  Macaca/MICROBIOLOGY  Macaca
       mulatta/*IMMUNOLOGY  RNA, Viral/BLOOD  Simian Acquired Immunodeficiency
       Syndrome/*IMMUNOLOGY  Species Specificity  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  SIV/*IMMUNOLOGY  T-Lymphocyte
       Subsets/IMMUNOLOGY  T-Lymphocytes, Cytotoxic/IMMUNOLOGY  Time Factors
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).