Document 0135
 DOCN  M9460135
 TI    [Changes of immunologic function in patients with COPD induced chronic
       cor pulmonale]
 DT    9404
 AU    Zhang J; Weng XZ; Ma L; Respiratory Department Beijing Red Cross
       Chaoyang Hospital.
 SO    Chung Hua Nei Ko Tsa Chih. 1993 Nov;32(11):746-9. Unique Identifier :
       AIDSLINE MED/94185454
 AB    We determined the counts of lymphocyte subpopulation CD3+, CD4+, CD8+
       and CD16+ in PBL by using APAAP method and some humoral immunological
       parameters (HIP) in patients with COPD induced chronic cor pulmonale.
       The results showed: (1) In cases during exacerbation stage, the counts
       of CD3+, CD4+, CD16+ and the CD4+:CD8+ ratio decreased remarkably (P <
       0.001). There was significant correlation between the counts of CD3+,
       CD4+, the CD4+:CD8+ ratio and PaO2 (P < 0.01). No marked change in serum
       IgG, IgA and IgM level was observed. Serum IgE and CIC level was
       significantly higher and C3 level lower than those in controls (P <
       0.01). After treatment the counts of CD3+, CD4+, CD16+ and the CD4+:CD8=
       ratio went up notably (P < 0.01), but no significant change was found in
       the HIP. (2) In cases during remission stage only the CD4+ level was low
       (P < 0.05) and no remarkable difference was observed in the HIP. After
       treatment with thymopeptide the counts of CD4+ increased (P < 0.05),
       CD8+ decreased (P < 0.01) and the CD4+:CD8+ ratio increased (P < 0.01).
       The serum IgA and CIC level also went up significantly (P < 0.05). This
       indicated that thymopeptide played a role in regulating the immunologic
       function.
 DE    Aged  CD4-CD8 Ratio  English Abstract  Female  Human  Lung Diseases,
       Obstructive/*COMPLICATIONS  Male  Middle Age  Peptides/THERAPEUTIC USE
       Pulmonary Heart Disease/ETIOLOGY/*IMMUNOLOGY/THERAPY  T-Lymphocyte
       Subsets/*IMMUNOLOGY  JOURNAL ARTICLE

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