Document 0141
 DOCN  M9460141
 TI    The interleukin-2 receptor subunit expression and function on peripheral
       blood lymphocytes from HIV-infected and control persons.
 DT    9404
 AU    Vanham G; Kestens L; Vingerhoets J; Penne G; Colebunders R;
       Vandenbruaene M; Goeman J; Ceuppens JL; Sugamura K; Gigase P; Institute
       of Tropical Medicine, Antwerp, Belgium.
 SO    Clin Immunol Immunopathol. 1994 Apr;71(1):60-8. Unique Identifier :
       AIDSLINE MED/94185340
 AB    The expression of interleukin-2 receptor (IL2R) was studied on
       circulating lymphocytes from HIV-infected (HIV+) and control subjects,
       using chain-specific monoclonal antibodies and indirect
       immunofluorescence flow cytometry. The IL2R alpha chain expression was
       decreased on CD4 and CD8 T cells from HIV+ persons compared to controls.
       Conversely, beta chain expression was enhanced on both T cell subsets
       from the patients. IL2R-subunit levels were similar on natural killer
       cells from patients and controls. To evaluate the function of IL2R, we
       investigated to what extent IL2 could induce CD69, an early activation
       marker of lymphocytes. A dose-dependent increase of CD69 expression was
       observed on T and NK cells from all subjects. The upregulation of CD69
       was similar on CD4 T and NK cells from patients and controls, but was
       more pronounced on CD8 T cells from HIV+ compared to HIV- subjects.
       Based on inhibition studies, both the alpha and the beta chain
       contributed to the IL-2-induced CD69 expression on CD4 T cells, pointing
       to involvement of the high-affinity receptor. The early activation of
       CD8 T cells and NK cells was mainly dependent on the
       intermediate-affinity receptor. We conclude that significant changes in
       IL2R alpha and beta chain expression on circulating T cells occur after
       HIV infection, but that early activation through IL2 is preserved or
       enhanced, even in advanced stages.
 DE    Adult  Antigens, CD/PHYSIOLOGY  Antigens, Differentiation,
       T-Lymphocyte/PHYSIOLOGY  Human  HIV Infections/METABOLISM/*PATHOLOGY
       HIV Seronegativity/PHYSIOLOGY  HIV
       Seropositivity/METABOLISM/PHYSIOPATHOLOGY  Receptors, Antigen, T-Cell,
       alpha-beta/ANTAGONISTS & INHIB/  PHYSIOLOGY  Receptors,
       Interleukin-2/*PHYSIOLOGY  Support, Non-U.S. Gov't  Up-Regulation
       (Physiology)/DRUG EFFECTS  JOURNAL ARTICLE

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