Document 0145
 DOCN  M9460145
 TI    Antigenic cross-reactivity between human T lymphotropic virus type I
       (HTLV-I) and retinal antigens recognized by T cells.
 DT    9404
 AU    Fukushima A; Ueno H; Fujimoto S; Department of Immunology, Kochi Medical
       School, Nankoku, Japan.
 SO    Clin Exp Immunol. 1994 Mar;95(3):459-64. Unique Identifier : AIDSLINE
       MED/94185316
 AB    To investigate the relationship between uveitis and HTLV-I infection, we
       examined the cross-reactivity between HTLV-I antigens and retinal
       antigens recognized by T cells in B10.BR mice immunized with human
       HTLV-I-infected MT-2 cells. We found that T cells obtained from MT-2
       immune mouse spleen responded not only to HTLV-I antigens but also to
       retinal antigens of various species. However, they did not respond to
       HTLV-I-negative lymphoid cell lines. Furthermore, established T cell
       lines from MT-2 immune spleen cells also responded to both HTLV-I and
       retinal antigens. The phenotype of the immune cells that responded to
       both HTLV-I and retinal antigens was CD4+, CD8-, and CD3+. The
       proliferative response of T cell lines to HTLV-I as well as various
       retinal antigens, was clearly blocked by addition of anti-CD3, anti-CD4,
       or anti-I-Ak MoAbs, but not by anti-CD8 antibody. The established T cell
       lines from HTLV-I immune spleen cells were all found to be CD3+, TCR
       beta +, CD4+, CD8- cells by flow cytometric analysis. These results
       indicate that an epitope of HTLV-I antigens is cross-reactive to an
       epitope of retinal antigens extracted from either human retinoblastoma
       or normal murine, rat, and bovine retinae at a T cell recognition level.
 DE    Animal  Antigens, CD/IMMUNOLOGY  Cattle  Cross Reactions  Eye
       Proteins/*IMMUNOLOGY  Human  HTLV-I/*IMMUNOLOGY  Lymphocyte
       Transformation  Mice  Phenotype  Rabbits  Rats  Retina/*IMMUNOLOGY
       Species Specificity  Spleen/IMMUNOLOGY  T-Lymphocyte Subsets/*IMMUNOLOGY
       JOURNAL ARTICLE

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