Document 0147
 DOCN  M9460147
 TI    HIV-1 infection of monocyte-derived macrophages reduces Fc and
       complement receptor expression.
 DT    9404
 AU    Kent SJ; Stent G; Sonza S; Hunter SD; Crowe SM; AIDS Pathogenesis
       Research Unit, Macfarlane Burnet Centre for; Medical Research,
       Fairfield, Australia.
 SO    Clin Exp Immunol. 1994 Mar;95(3):450-4. Unique Identifier : AIDSLINE
       MED/94185314
 AB    Fc receptor (FcR) and complement receptor (CR) expression on
       HIV-infected monocyte-derived macrophages may be an important
       determinant of immune function. We studied the effects of HIV-1
       infection of macrophages in vitro on FcR and CR expression. Macrophages
       were infected with HIV-1DV 7 days following isolation, and the
       expression of Fc gamma RI-III and CR3 were measured at intervals
       thereafter by flow cytometry. We found a reduction in receptor
       expression with the percentage of cells expressing FcRI 14 days post
       infection declining from 77% to 13%, FcRII fell from 96% to 85%, FcRIII
       from 45% to 9%, and CR3 from 91% to 67% 14 days following infection. As
       these receptors are important for macrophage function, their
       down-modulation may contribute to the pathogenesis of HIV-related
       disease.
 DE    Cell Adhesion Molecules/BIOSYNTHESIS  Human  HIV-1/*GROWTH & DEVELOPMENT
       Macrophage-1 Antigen/*BIOSYNTHESIS  Macrophages/*IMMUNOLOGY/MICROBIOLOGY
       Monocytes/*IMMUNOLOGY/MICROBIOLOGY  Receptors, Fc/*BIOSYNTHESIS
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

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