Document 0156
 DOCN  M9460156
 TI    Allogeneic bone marrow transplantation combined with multiple anti-HIV-1
       treatment in a case of AIDS.
 DT    9404
 AU    Contu L; La Nasa G; Arras M; Pizzati A; Vacca A; Carcassi C; Ledda A;
       Boero R; Orru S; Pintus A; et al; Istituto di Clinica Medica, Universita
       di Cagliari, Italy.
 SO    Bone Marrow Transplant. 1993 Dec;12(6):669-71. Unique Identifier :
       AIDSLINE MED/94184273
 AB    A 25-year-old woman with AIDS was submitted to HLA-identical allogeneic
       BMT after cytoablation with busulphan and cyclophosphamide and combined
       anti-HIV-1 therapy with zidovudine, IFN-alpha 2 and anti-HIV-1-specific
       T cell clones. Marrow engraftment occurred after 18 days and tests for
       HIV-1 were negative after 30 days but the hematologic reconstitution of
       the patient was poor. A second BM infusion from the same donor was
       ineffective and treatment with GM-CSF only induced a transient increase
       of the blood cell count, suggesting iatrogenic damage to the BM
       microenvironment. The development of ARDS led to the death of the
       patient 10 months after transplantation. Post-mortem investigation did
       not reveal any active infections and PCR on autopsy tissues was negative
       for HIV-1.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*SURGERY/THERAPY  Adult
       Antilymphocyte Serum/ADMINISTRATION & DOSAGE  *Bone Marrow
       Transplantation/ADVERSE EFFECTS/IMMUNOLOGY/METHODS
       Busulfan/ADMINISTRATION & DOSAGE  Case Report  Combined Modality Therapy
       Cyclophosphamide/ADMINISTRATION & DOSAGE  Drug Therapy, Combination
       Female  Graft vs Host Disease/IMMUNOLOGY  Granulocyte-Macrophage
       Colony-Stimulating Factor/ADMINISTRATION &  DOSAGE  Human
       *HIV-1/ISOLATION & PURIF  Interferon Alfa-2b/ADMINISTRATION & DOSAGE
       Respiratory Distress Syndrome, Adult/ETIOLOGY  Support, Non-U.S. Gov't
       Transplantation, Homologous  Zidovudine/ADMINISTRATION & DOSAGE  JOURNAL
       ARTICLE

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