Document 0170
 DOCN  M9460170
 TI    Interaction of hepatitis B and hepatitis C infection in haemophilia.
 DT    9404
 AU    Hanley JP; Dolan G; Day S; Skidmore SJ; Irving WL; Department of
       Haematology, University Hospital, Nottingham.
 SO    Br J Haematol. 1993 Nov;85(3):611-2. Unique Identifier : AIDSLINE
       MED/94183741
 AB    The management of haemophilia has been greatly complicated by the
       clinical sequelae of viral infection acquired through contaminated blood
       products. Many haemophiliacs have been infected by several viruses and
       the interaction between these viruses may be complex. In a cohort of 42
       anti-HCV positive haemophiliacs, five were also found to be positive for
       HBsAg. All five were HCV reverse transcriptase/PCR negative compared to
       the 4/37 (11%) anti-HCV positive haemophiliacs who were HBsAg negative
       (P = 0.0001). We have identified a striking interaction between
       hepatitis C (HCV) and hepatitis B (HBV) in haemophiliacs co-infected by
       these agents, suggestive of the phenomenon of viral interference.
 DE    Cohort Studies  Hemophilia/*COMPLICATIONS  Hepatitis B/*COMPLICATIONS
       Hepatitis C/*COMPLICATIONS  Human  HIV Infections/COMPLICATIONS  Male
       Polymerase Chain Reaction  Reverse Transcriptase  Viral Interference
       JOURNAL ARTICLE

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