Document 0188
 DOCN  M9460188
 TI    Comparative studies on IL-6 production status in HTLV-1 chronically
       infected cell lines derived from different HTLV-1 associated
       pathologies.
 DT    9404
 AU    Saib A; Saal F; Giron ML; Valla J; Hojman F; Peries J; Canivet M; UPR
       A0043 CNRS, Hopital Saint Louis, Paris, France.
 SO    J Biol Regul Homeost Agents. 1993 Jul-Sep;7(3):79-84. Unique Identifier
       : AIDSLINE MED/94182493
 AB    We have comparatively studied the qualitative and quantitative status of
       Interleukin 6 (IL-6) production in several HTLV-1 chronically infected
       T-cell lines derived from patients suffering either of adult-T-cell
       leukemia/lymphoma or of tropical spastic paraparesis (TSP). Two other
       HTLV-1 chronically infected cell lines, coming from healthy seropositive
       carriers, were also analyzed. Our results demonstrate that,
       independently of the origin, all these T cell lines, as compared to
       uninfected HTLV-1 T cell ones, which were always IL-6 non producers,
       synthesize and yield comparable amounts of IL-6 synthesis, he
       nosological origin of infecting viral strains does not seem to play a
       differential role on IL-6 qualitative or quantitative production
       parameters.
 DE    Blotting, Northern  Cell Line  Comparative Study  Fluorescent Antibody
       Technique  Human  HTLV-I/*PATHOGENICITY
       Interleukin-6/ANALYSIS/*BIOSYNTHESIS/GENETICS  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).