Document 0195
 DOCN  M9460195
 TI    Relationship between serum cyclo(His-Pro) concentrations and the
       nutritional status of HIV-infected patients.
 DT    9404
 AU    Wisniewski TL; Mendel E; Morse EV; Hilton CW; Svec F; Obesity Research
       Program, Louisiana State University Medical; Center, School of Medicine,
       New Orleans.
 SO    South Med J. 1994 Mar;87(3):348-51. Unique Identifier : AIDSLINE
       MED/94182159
 AB    Cyclo(His-Pro) (CHP) is a gut-neuropeptide that influences both appetite
       and carbohydrate metabolism. This study was undertaken to determine
       whether concentrations of CHP correlated with various clinical markers
       of nutritional status and progression of HIV infection. Serum
       concentrations of CHP were analyzed in a clinical sample of 100
       HIV-positive patients whose HIV clinical status ranged from asymptomatic
       to advanced disease with weight loss. We found a relationship between
       CHP concentrations and serum albumin and hemoglobin levels, markers of
       chronic nutrition and disease. However, no correlation was seen between
       CHP and cortisol concentrations, a marker of acute stress. To analyze
       the relationship of HIV clinical stage and CHP, patients were divided
       into three subgroups: asymptomatic, mildly symptomatic, and clear-cut
       AIDS. CHP concentrations were significantly correlated with HIV clinical
       stage. These data lead to the hypothesis that CHP is a marker of disease
       progression and that it potentially plays a role in modulating the
       nutrition of HIV-infected patients.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD  Adolescence  Adult  Aged
       Hemoglobins/ANALYSIS  Human  Hydrocortisone/BLOOD  HIV
       Seropositivity/*BLOOD  Middle Age  *Nutritional Status  Peptides,
       Cyclic/*BLOOD  Piperazines/*BLOOD  Prasterone/ANALOGS &
       DERIVATIVES/BLOOD  Sarcoma, Kaposi's/BLOOD  Serum Albumin/ANALYSIS
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).