Document 0207
 DOCN  M9460207
 TI    Alteration in the proportion of CD4 T lymphocytes in a subgroup of human
       immunodeficiency virus-exposed-uninfected children.
 DT    9404
 AU    Gesner M; Papaevangelou V; Kim M; Chen SH; Moore T; Krasinski K;
       Borkowsky W; Department of Pediatrics, New York University Medical
       Center, NY; 10016.
 SO    Pediatrics. 1994 Apr;93(4):624-30. Unique Identifier : AIDSLINE
       MED/94181382
 AB    OBJECTIVE. The age-related changes in the proportion of CD4 and CD8
       lymphocytes in human immunodeficiency virus (HIV)-seronegative children
       born to HIV-infected mothers (seroreverters) were compared with the
       changes in these lymphocyte subsets in children born to seronegative
       women to assess a possible effect of exposure to HIV without infection.
       DESIGN. There were 146 seroreverter and 72 seronegative children. The
       median CD4 and CD8 percentages for each of these two groups of children
       were compared retrospectively at 3-month intervals from birth through 27
       months and at a tenth interval for the time beyond 27 months. The
       weighted average of the within-subject rate of change of CD4 and CD8
       percentages were also compared between the two groups. Finally, for each
       subject, the proportion of the subject's CD4 percentage assays which
       were <10th percentile of the entire study population (30%) was
       calculated, and the distributions of the subject-specific proportions
       were then compared between the seronegative and seroreverter groups
       using the Wilcoxon rank sum test. The proportion of CD8 assays <10th
       percentile (12%) or > 90th percentile (26%) were also computed for each
       subject, and the distributions of the proportions were compared
       similarly. . RESULTS. The median CD4 percentage of seroreverter children
       was lower than that for the seronegative children at every interval from
       birth through 27 months and for the last interval for values obtained at
       greater than 27 months, although the comparison was statistically
       significant only at the 4- to 6-month period. The weighted average of
       the within-subject rate of change of CD4 percentage was -0.09 and -3.0
       per year (P = .04), and of CD8 percentage was 1.3 and 1.0 (P = .67), for
       the seroreverter and seronegative children, respectively. There were
       significantly more children in the seroreverter group than in the
       seronegative group who had repeated assays in which the CD4 percentage
       was < 10th percentile for age (P < .00005). In addition, there was a
       subset of 10 seroreverter children (6.8%) who had CD4 percentages < 30%
       on > 50% of their assays, as compared with only one (1.4%) seronegative
       child. The proportion of CD8 assays < 10th percentile or > 90th
       percentile were not significantly different between the two groups of
       children. CONCLUSIONS. The CD4 proportions were persistently lower in
       the seroreverter than in the seronegative population, although only
       reaching statistical significance in 1 of 10 3-month intervals. This
       finding may be due to a subgroup of seroreverter children who have
       persistently low CD4 lymphocyte percentages.
 DE    Comparative Study  *CD4-CD8 Ratio  Female  Human  HIV
       Infections/TRANSMISSION  HIV Seronegativity/*IMMUNOLOGY  HIV
       Seropositivity/*IMMUNOLOGY  Infant  Male  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).