Document 0242
 DOCN  M9460242
 TI    Relationship of serum levels of oncostatin M to AIDS-related and classic
       Kaposi's sarcoma.
 DT    9404
 AU    Hamilton AS; Radka SF; Bernstein L; Gill PS; Gonsalves M; Naemura JR;
       Ross RK; University of Southern California School of Medicine,
       Department; of Preventive Medicine, Los Angeles.
 SO    J Acquir Immune Defic Syndr. 1994 Apr;7(4):410-4. Unique Identifier :
       AIDSLINE MED/94180317
 AB    Serum levels of circulating oncostatin-M (OM) were compared among cases
       of Kaposi's sarcoma associated with acquired immune deficiency syndrome
       (AIDS-KS) and multiple controls, including a homosexual man infected
       with human immunodeficiency virus type 1 (HIV-1), an HIV-1-uninfected
       homosexual man, and a heterosexual man; and among classic KS cases and
       heterosexual controls. Cases were selected from abstracts collected by a
       population-based cancer registry and from local AIDS clinics. Controls
       for the AIDS-KS cases were matched to the cases by age, sex, and race
       and were either friends of the cases or residents from the cases'
       neighborhoods; controls for the classic KS cases were similarly matched,
       but were obtained solely from neighborhood residents. Blood samples were
       obtained from participants, serum levels of OM were determined by
       enzyme-linked immunosorbent assay (ELISA), and CD4 cell counts were
       obtained by flow cytometry. Geometric mean levels of OM were compared
       among the risk groups adjusted for age and CD4 cell count. No
       differences in adjusted OM levels were found between AIDS-KS cases and
       HIV-1-infected homosexual controls (8.4 pg/ml vs. 10.2) or between
       classic KS cases and controls (13.3 pg/ml vs. 9.6); however the
       HIV-1-infected controls (both homosexual and heterosexual) matched to
       the AIDS-KS cases had higher levels than did the HIV-1-infected cases
       and controls. Among the HIV-1-infected groups, an inverse correlation
       between OM and CD4 cell count was observed and was statistically
       significant for the cases. Among all heterosexual controls (matched to
       either case group), serum OM was inversely related to age.(ABSTRACT
       TRUNCATED AT 250 WORDS)
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  Age Factors
       Aged  Case-Control Studies  Cytokines/BLOOD  Growth Substances/*BLOOD
       Homosexuality  Human  *HIV-1  Leukocyte Count  Male  Middle Age
       Peptides/*BLOOD  Sarcoma, Kaposi's/*BLOOD/ETIOLOGY/PATHOLOGY  Sex
       Behavior  Support, U.S. Gov't, P.H.S.  T4 Lymphocytes  JOURNAL ARTICLE

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