Document 0254
 DOCN  M9460254
 TI    Comparison of anti-HIV-1 ADCC reactivities in infected humans and
       chimpanzees.
 DT    9404
 AU    Ferrari G; Place CA; Ahearne PM; Nigida SM Jr; Arthur LO; Bolognesi DP;
       Weinhold KJ; Laboratorio di Virologia, Ospedale S. Raffaele, Milan,
       Italy.
 SO    J Acquir Immune Defic Syndr. 1994 Apr;7(4):325-31. Unique Identifier :
       AIDSLINE MED/94180305
 AB    Despite its shortcomings as a disease model, the chimpanzee is still the
       most relevant animal model for human immunodeficiency virus type 1
       (HIV-1) infection. Previous studies have revealed qualitative
       differences between human and chimpanzee anti-HIV-1 responses. In this
       study, the development of specific anti-HIV-1 antibody-dependent
       cellular cytotoxic (ADCC) reactivities was evaluated in chronically
       infected chimpanzees and compared to the human response, because
       anti-HIV-1 ADCC represents a major component of anti-envelope cytolytic
       response found in infected patients. Ten HIV-1-infected chimpanzees up
       to 5 years after the infection were investigated. Anti-HIV-1
       ADCC-directing antibodies were detectable in only three of 10 infected
       chimpanzees, and in these animals, activity was apparent only several
       months after the HIV infection. In some of the infected animals, ADCC
       reactivity against infected cells preceded reactivity against
       gp120-coated targets. When anti-gp120 ADCC-directing antibodies were
       apparent, they exhibited the same broad reactivity described in humans
       against different HIV isolates. The pattern of ADCC reactivities in
       infected chimpanzees is completely different from the well-characterized
       anti-gp120 cytotoxic reactivities present in HIV-1-infected patients. It
       is a relatively rare and late-occurring event that may have an important
       bearing on the lack of virus-induced pathogenesis in the chimpanzee
       model.
 DE    Animal  *Antibody-Dependent Cell Cytotoxicity  Cell Line  *Chimpansee
       troglodytes/IMMUNOLOGY/MICROBIOLOGY  Comparative Study  *Disease Models,
       Animal  Human  HIV Antibodies/BLOOD  HIV Envelope Protein
       gp120/IMMUNOLOGY  HIV Envelope Protein gp41/IMMUNOLOGY  HIV
       Infections/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY  Immune Sera/IMMUNOLOGY
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).