Document 0255
 DOCN  M9460255
 TI    Functional comparison between HTLV-I envelopes originating from TSP/HAM
       or ATL cell lines.
 DT    9404
 AU    Pique C; Saal F; Peries J; Pham D; Tursz T; Dokhelar MC; CNRS URA 1156,
       Institut Gustave Roussy, Villejuif, France.
 SO    J Acquir Immune Defic Syndr. 1994 Apr;7(4):319-24. Unique Identifier :
       AIDSLINE MED/94180304
 AB    The human T-cell leukemia type I (HTLV-I) virus is associated with two
       different diseases, adult T-cell leukemia (ATL) and tropical spastic
       paraparesis/HTLV-I-associated myelopathy (TSP/HAM). We have compared the
       viral envelopes originating from TSP/HAM and ATL patients, using the
       capacity of infected cells to form syncytia with receptor-expressing
       cells. We show that like the ATL cell lines, the TSP/HAM ones can form
       syncytia with a large panel of human target cells, including a variety
       of hematopoietic cell lines, as well as cell lines of neuroectodermal
       origin. None of the target cell lines tested was able to discriminate
       between TSP/HAM- and ATL-infected cell lines. When infected cells of
       TSP/HAM origin are cocultivated with cells of ATL origins, syncytia are
       never observed. This interference phenomenon suggests that the viruses
       expressed by the different cell lines utilize the same receptor.
 DE    Blotting, Western  Cell Line  Comparative Study  Fluorescent Antibody
       Technique  Giant Cells  Hematopoietic Stem Cells/CYTOLOGY  Human
       HTLV-I/*PHYSIOLOGY  Leukemia, T-Cell/*MICROBIOLOGY/PATHOLOGY
       Paraparesis, Tropical Spastic/*MICROBIOLOGY/PATHOLOGY  Receptors,
       Virus/PHYSIOLOGY  Support, Non-U.S. Gov't
       T-Lymphocytes/CYTOLOGY/*MICROBIOLOGY  Tumor Cells, Cultured  Viral
       Envelope Proteins/*PHYSIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).