Document 0259
 DOCN  M9460259
 TI    The mechanism of thrombocytopenia in patients with HIV infection.
 DT    9404
 AU    Najean Y; Rain JD; Department of Nuclear Medicine, Saint-Louis Hospital
       1, Paris,; France.
 SO    J Lab Clin Med. 1994 Mar;123(3):415-20. Unique Identifier : AIDSLINE
       MED/94179958
 AB    From a retrospective analysis of 85 patients with thrombocytopenia and
       HIV infection, in whom platelet production and destruction were studied
       by isotopic methods, the following conclusions are drawn. In most
       recently infected patients thrombocytopenia is due to accelerated
       platelet destruction; in these patients the platelet sequestration is
       predominantly splenic, and splenectomy is usually effective. The same
       pattern is seen in approximately one third of patients with more
       advanced disease (i.e., those with AIDS-related complex or frank AIDS).
       In most patients with AIDS-related complex or AIDS, the thrombocytopenia
       is due chiefly to a platelet production defect; splenectomy is less
       likely to help and is thus generally inadvisable. When the patients who
       were receiving zidovudine were examined separately, they were found to
       have a lesser rate of platelet destruction but also to have a more
       prominent defect in platelet production defect. This suggests that the
       drug may help blunt platelet destruction but may do so at a price in
       marrow response to the thrombocytolysis.
 DE    Adolescence  Adult  Azathioprine/THERAPEUTIC USE  Blood
       Platelets/PHYSIOLOGY  Cell Survival/DRUG EFFECTS  Female  Human  HIV
       Infections/BLOOD/*COMPLICATIONS/DRUG THERAPY  Kinetics  Male  Middle Age
       Thrombocytopenia/BLOOD/*ETIOLOGY  JOURNAL ARTICLE

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