Document 0262
 DOCN  M9460262
 TI    Association of rotavirus and human immunodeficiency virus infection in
       children hospitalized with acute diarrhea, Lusaka, Zambia.
 DT    9404
 AU    Oshitani H; Kasolo FC; Mpabalwani M; Luo NP; Matsubayashi N; Bhat GH;
       Suzuki H; Numazaki Y; Zumla A; DuPont HL; Department of Virology,
       University Teaching Hospital, Lusaka,; Zambia.
 SO    J Infect Dis. 1994 Apr;169(4):897-900. Unique Identifier : AIDSLINE
       MED/94179908
 AB    In Lusaka, Zambia, rotavirus (RV) and human immunodeficiency virus (HIV)
       infection commonly coexist; 132 (25%) of 537 consecutively studied
       infants < 5 years old hospitalized with diarrhea were positive for both
       viral infections. Infants with RV infection were younger than those who
       were RV-negative (P > .05), and infants with both viruses more
       frequently experienced dehydration (P < .05). HIV-infected children more
       often exhibited respiratory symptoms on admission to the study (P <
       .0001) and were more frequently underweight (P < .0001) than were
       HIV-negative children, independent of RV infection. The mortality rate
       was highest in HIV-positive infants (P < .05), and coinfection with RV
       did not increase the risk of fatality. This study demonstrates that
       while RV and HIV infections commonly coexist in one region of Africa, RV
       infection is no more common nor is the illness more severe in
       HIV-positive infants.
 DE    Acute Disease  Age Factors  Antigens, Viral/ANALYSIS  Chi-Square
       Distribution  Child, Preschool  Diarrhea/*COMPLICATIONS/MORTALITY
       Diarrhea, Infantile/*COMPLICATIONS/MORTALITY  Feces/MICROBIOLOGY  Human
       HIV Antibodies/BLOOD  HIV Infections/*COMPLICATIONS/MORTALITY
       HIV-1/*IMMUNOLOGY  Infant  Microscopy, Electron  Odds Ratio
       Protein-Energy Malnutrition/COMPLICATIONS
       Rotavirus/IMMUNOLOGY/ULTRASTRUCTURE  Rotavirus
       Infections/*COMPLICATIONS/MORTALITY  Support, Non-U.S. Gov't  Support,
       U.S. Gov't, P.H.S.  Zambia  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).