Document 0264
 DOCN  M9460264
 TI    Subnormal serum concentration of 1,25-vitamin D in human
       immunodeficiency virus infection: correlation with degree of immune
       deficiency and survival.
 DT    9404
 AU    Haug C; Muller F; Aukrust P; Froland SS; Kaptein Wilhelmsen og Frues
       Institute of Bacteriology, Medical; Department A, University of Oslo,
       National Hospital, Norway.
 SO    J Infect Dis. 1994 Apr;169(4):889-93. Unique Identifier : AIDSLINE
       MED/94179906
 AB    Vitamin D metabolites, immunologic, virologic, and clinical parameters,
       and survival time were determined in 22 asymptomatic human
       immunodeficiency virus (HIV)-infected patients (CDC stage II/III), 31
       symptomatic HIV-infected patients (CDC stage IV), and 28
       HIV-seronegative controls. Significantly lower serum levels of
       1,25-vitamin D (1,25D) were found in symptomatic patients (median, 34
       pg/mL; 25th-75th percentile, 21-45) compared with controls (49 pg/mL;
       39-59) and asymptomatic patients (45 pg/mL; 42-50). In HIV-infected
       subjects, the serum level of 1,25D was positively correlated with CD4+
       cell counts in peripheral blood (r = .35, P < .05) and negatively
       correlated with the level of serum neopterin (r = -.36, P < .01).
       HIV-infected patients with abnormally low 1,25D (< 25 pg/mL) also had
       shorter survival times than other HIV-infected subjects (P < .01). Low
       1,25D levels did not appear to be related to vitamin D deficiency.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/COMPLICATIONS/DRUG
       THERAPY/MORTALITY  Biopterin/ANALOGS & DERIVATIVES/BLOOD
       Calcitriol/*BLOOD  Follow-Up Studies  Human  HIV
       Infections/*BLOOD/COMPLICATIONS/DRUG THERAPY/MORTALITY
       Ketoconazole/THERAPEUTIC USE  Leukocyte Count  Nutrition
       Disorders/COMPLICATIONS  Proportional Hazards Models  Support, Non-U.S.
       Gov't  Survival Analysis  T-Lymphocytes, Suppressor-Effector  T4
       Lymphocytes  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).