Document 0266
 DOCN  M9460266
 TI    Provirus copy number to predict disease progression in asymptomatic
       human immunodeficiency virus type 1 infection.
 DT    9404
 AU    Chevret S; Kirstetter M; Mariotti M; Lefrere F; Frottier J; Lefrere JJ;
       Departement de Biostatistique et Informatique Medicale,; Hopital
       Saint-Louis, Paris, France.
 SO    J Infect Dis. 1994 Apr;169(4):882-5. Unique Identifier : AIDSLINE
       MED/94179904
 AB    To evaluate the prognostic value of provirus copy number through
       quantitative DNA polymerase chain reaction (PCR) in early stages of
       human immunodeficiency virus type 1 (HIV-1) infection, 42 untreated and
       asymptomatic HIV-1-seropositive subjects with baseline CD4+ cell counts
       > 200 x 10(6)/L were included in a prospective study and followed over a
       median of 27 months. Disease progression was defined as decrease in CD4+
       cells to < 200 (14 events). At enrollment, provirus copy number was
       associated with CD4+ cell count and percentage, serum IgA, and p24
       antigenemia. Elevated provirus copy number above 20 allowed
       identification of patients at high risk of a subsequently decreasing
       CD4+ cell count, even after adjusting for baseline CD4+ cell count (P =
       .003). Measuring provirus copy number by PCR at early stages of HIV-1
       infection could offer a useful early means to predict progression to
       AIDS.
 DE    Adult  Cohort Studies  DNA, Viral/ANALYSIS  Female  Follow-Up Studies
       Human  HIV Infections/ETIOLOGY/*MICROBIOLOGY  HIV-1/*GROWTH &
       DEVELOPMENT/GENETICS  Leukocyte Count  Male  Middle Age  Polymerase
       Chain Reaction  Prognosis  Prospective Studies  Proviruses/*GROWTH &
       DEVELOPMENT/GENETICS  Support, Non-U.S. Gov't  T4
       Lymphocytes/*MICROBIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).