Document 0267
 DOCN  M9460267
 TI    Hemorrhagic fever with renal syndrome: relationship between pathogenesis
       and cellular immunity.
 DT    9404
 AU    Huang C; Jin B; Wang M; Li E; Sun C; Department of Immunology, Fourth
       Military Medical University,; Xi'an, People's Republic of China.
 SO    J Infect Dis. 1994 Apr;169(4):868-70. Unique Identifier : AIDSLINE
       MED/94179900
 AB    After phenotype analysis of peripheral blood mononuclear cells (PBMC),
       soluble interleukin-2 receptor (sIL-2R) levels in plasma or sera from
       patients with hemorrhagic fever with renal syndrome (HFRS) were
       measured. The results showed the ratio of activated antigen (CD25,
       TLiSA1, CD71, and Ia)-positive lymphocytes of PBMC in the acute phase of
       HFRS was higher than that in convalescent phase. Moreover, there was
       much higher expression of heteromorphologic lymphocytes than of small
       lymphocytes. Decreases in T lymphocytes and CD4:CD8 ratios were seen
       with increases in B lymphocyte ratios and interferon-gamma (IFN-gamma)
       expression on PBMC surfaces in the acute phase of HFRS.
       IFN-gamma-positive lymphocytes included CD4, CD8, and CD56 subsets.
       sIL-2R levels were much higher in sera and plasma in the acute phase,
       especially the oliguric phase. These findings suggest that patients with
       HFRS are in a state of high-level cellular immune response, which may be
       involved in the development of inflammation and pathologic lesions.
 DE    Acute Disease  Adult  Antigens, CD/*ANALYSIS/BIOSYNTHESIS  Antigens,
       Differentiation, B-Lymphocyte/ANALYSIS  Centrifugation, Density Gradient
       Chronic Disease  CD4-CD8 Ratio  Female  Hemorrhagic Fever,
       Epidemic/ETIOLOGY/*IMMUNOLOGY  Human  Immunity, Cellular  Interferon
       Type II/BIOSYNTHESIS  Lymphocyte Subsets/*IMMUNOLOGY  Male  Receptors,
       Interleukin-2/*BIOSYNTHESIS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).