Document 0268
 DOCN  M9460268
 TI    Persistent cytomegalovirus infection of semen increases risk of AIDS.
 DT    9404
 AU    Detels R; Leach CT; Hennessey K; Liu Z; Visscher BR; Cherry JD; Giorgi
       JV; Los Angeles Center of the Multicenter AIDS Cohort Study,; University
       of California, Los Angeles 90024-1772.
 SO    J Infect Dis. 1994 Apr;169(4):766-8. Unique Identifier : AIDSLINE
       MED/94179885
 AB    To evaluate if persistent cytomegalovirus (CMV) infection of semen in
       human immunodeficiency virus type 1 (HIV-1) antibody-positive men
       increases AIDS risk, serial cultures for CMV every 3-6 months were
       attempted four or more times from 164 men followed 3 years. CMV was
       never isolated from 58 men, in 1 or 2 samples from 54 (intermittently
       positive), and in > or = 3 samples from 52 (persistently positive). The
       Cox model was used to estimate relative hazards while controlling for
       CD4 cell number. The relative hazard was 2.9 for those intermittently
       and 4.0 for those persistently positive (P < .001). No Kaposi's sarcoma
       occurred in culture-negative men, 3 cases (5.6%) in intermittently
       positive men, and 4 cases (7.7%) in persistently positive men (P < .04).
       Persistent CMV in semen increases the hazard of AIDS in HIV-1
       antibody-positive men, possibly by activating CD4 cells to produce
       HIV-1. Thus, control of CMV in HIV-1-infected persons may slow
       progression to AIDS.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/ETIOLOGY  Adult
       Bisexuality  Cohort Studies  Cytomegalovirus/*PHYSIOLOGY
       Cytomegalovirus Infections/*COMPLICATIONS  Follow-Up Studies
       Homosexuality  Human  Male  Proportional Hazards Models  Risk Factors
       Sarcoma, Kaposi's/COMPLICATIONS/ETIOLOGY  Semen/*MICROBIOLOGY  Support,
       U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).