Document 0269
 DOCN  M9460269
 TI    Salmonella typhimurium induces expression of P glycoprotein (multidrug
       resistance 1 gene product) in a promonocytic cell line chronically
       infected with human immunodeficiency virus type 1.
 DT    9404
 AU    Andreana A; Gollapudi S; Gupta S; Division of Basic and Clinical
       Immunology, University of; California, Irvine.
 SO    J Infect Dis. 1994 Apr;169(4):760-5. Unique Identifier : AIDSLINE
       MED/94179884
 AB    This investigation showed that phagocytosis of virulent Salmonella
       typhimurium by promonocytic leukemia cell line U1, which contains human
       immunodeficiency virus type 1 (HIV-1) provirus but produces minimal or
       no virus, and not by uninfected U937 cell line resulted in expression of
       a functional P glycoprotein. Anti-tumor necrosis factor-alpha (TNF
       alpha) monoclonal antibody failed to inhibit S. typhimurium-induced P
       glycoprotein expression. Furthermore, recombinant TNF alpha had no
       effect on the induction of P glycoprotein expression in U1 cells. These
       data demonstrate that phagocytosis of virulent S. typhimurium results in
       an induction of P glycoprotein in association with HIV-1 infection;
       however, TNF alpha does not appear to play a significant role. Thus,
       secondary microbial infection in HIV-1-positive persons may play a role
       in multidrug resistance against antiviral and other antimicrobial agents
       by an induction of P glycoprotein.
 DE    Carrier Proteins/*BIOSYNTHESIS/GENETICS  Cell Line  Drug Resistance,
       Microbial/GENETICS  Gene Expression Regulation  HIV-1/*PHYSIOLOGY
       Membrane Glycoproteins/*BIOSYNTHESIS/GENETICS  Phagocytosis  Salmonella
       typhimurium/IMMUNOLOGY/*PHYSIOLOGY/PATHOGENICITY  Support, Non-U.S.
       Gov't  Tumor Necrosis Factor/PHYSIOLOGY  Virulence  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).