Document 0272
 DOCN  M9460272
 TI    Soluble receptors for tumor necrosis factor as predictors of progression
       to AIDS in asymptomatic human immunodeficiency virus type 1 infection.
 DT    9404
 AU    Godfried MH; van der Poll T; Weverling GJ; Mulder JW; Jansen J; van
       Deventer SJ; Sauerwein HP; Department of Internal Medicine, University
       of Amsterdam,; Netherlands.
 SO    J Infect Dis. 1994 Apr;169(4):739-45. Unique Identifier : AIDSLINE
       MED/94179881
 AB    Serum concentrations of soluble receptors for tumor necrosis
       factor-alpha (sTNF alpha R) types I and II, beta 2-microglobulin, and
       CD4 cell counts were determined at entry and 3-5 months before AIDS
       diagnosis in 20 untreated, asymptomatic human immunodeficiency virus
       type 1 (HIV-1)-seropositive subjects, who progressed to AIDS within 5.5
       years of study entry, and in an equal number of HIV-seronegative and
       untreated seropositive controls, who remained asymptomatic. At entry,
       concentrations of sTNF alpha R type II and beta 2-microglobulin were
       elevated and increased further in progressors. The odds ratio (OR) for
       sTNF alpha R type II concentrations > or = 6.5 ng/mL was 18.4 and for
       beta 2-microglobulin concentrations > or = 3 mg/L was 6.6; CD4 cell
       counts were not predictive. Five months before diagnosis, the OR was
       102.0 for sTNF alpha R type II concentrations > or = 7.5 ng/mL, 13.5 for
       beta 2-microglobulin concentrations > or = 4 mg/L, and 6.9 for CD4 cell
       counts < 250/mm3 (counts < 500/mm3 were not predictive). Of the three
       variables, sTNF alpha R type II was proved by bivariate analysis to be
       the strongest and earliest predictor of disease progression.
 DE    beta 2-Microglobulin/ANALYSIS  Acquired Immunodeficiency
       Syndrome/*ETIOLOGY  Adult  Case-Control Studies  Cohort Studies
       Comparative Study  Confidence Intervals  Follow-Up Studies  Human  HIV
       Seropositivity/*IMMUNOLOGY  *HIV-1  Leukocyte Count  Male  Odds Ratio
       Predictive Value of Tests  Prospective Studies  Receptors, Tumor
       Necrosis Factor/*ANALYSIS  Regression Analysis  Support, Non-U.S. Gov't
       Time Factors  T4 Lymphocytes  JOURNAL ARTICLE

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