Document 0273
 DOCN  M9460273
 TI    Expression of costimulatory molecule CD28 on T cells in human
       immunodeficiency virus type 1 infection: functional and clinical
       correlations.
 DT    9404
 AU    Brinchmann JE; Dobloug JH; Heger BH; Haaheim LL; Sannes M; Egeland T;
       Institute of Transplantation Immunology, National Hospital, Oslo,;
       Norway.
 SO    J Infect Dis. 1994 Apr;169(4):730-8. Unique Identifier : AIDSLINE
       MED/94179880
 AB    To study the functional integrity of T cells from human immunodeficiency
       virus type 1 (HIV-1)-infected persons, CD4+ and CD8+ cells were examined
       for proliferation and secretion of interleukin-2 (IL-2) in response to
       staphylococcal superantigens and antibodies to CD3 and the alpha beta T
       cell receptor. A functional defect within CD8+ but not within CD4+ cells
       from HIV-1-infected persons was observed. Within CD8+ cells,
       proliferation and secretion of IL-2 was restricted to cells expressing
       the costimulatory molecule CD28. Such cells were proportionally reduced
       in HIV-1-infected persons. In patients with advanced immunodeficiency,
       however, evidence of functional derangement was found also within the
       CD28+ CD8+ cells. In a cross-sectional study of 73 HIV-infected persons
       and 15 controls, a significant correlation was observed between the
       number of CD28+ CD8+ cells and the presence of HIV-related disease. Our
       results suggest that regulation of expression of CD28 may play an
       important role in the immunopathogenesis of AIDS.
 DE    Antigens, CD28/*BIOSYNTHESIS  Antigens, CD4/ANALYSIS  Antigens,
       CD8/ANALYSIS  Case-Control Studies  Cross-Sectional Studies  CD4-CD8
       Ratio  Flow Cytometry  Human  HIV Infections/*IMMUNOLOGY  *HIV-1
       Interleukin-2/BIOSYNTHESIS  Lymphocyte Transformation  Support, Non-U.S.
       Gov't  T-Lymphocytes/*IMMUNOLOGY  T-Lymphocytes,
       Suppressor-Effector/IMMUNOLOGY  T4 Lymphocytes/IMMUNOLOGY  JOURNAL
       ARTICLE

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