Document 0290
 DOCN  M9460290
 TI    Treatment of human immunodeficiency virus infection and its associated
       complications in children.
 DT    9404
 AU    Brady MT; College of Medicine, Ohio State University, Columbus.
 SO    J Clin Pharmacol. 1994 Jan;34(1):17-29. Unique Identifier : AIDSLINE
       MED/94179577
 AB    Providing care to human immunodeficiency virus (HIV)-infected children
       requires a comprehensive, multidisciplinary approach. This review will
       address the current status of supportive care, treatment of
       HIV-associated complications and specific antiretroviral therapy. HIV
       affects multiple locations in the body resulting in a myriad of possible
       complications. These include opportunistic infections and malignancies
       secondary to immunodeficiency and central nervous system or other
       specific organ-related disease secondary to direct HIV involvement.
       Recent scientific advances have markedly enhanced the quantity and
       quality of life of HIV-infected children. Prophylaxis of Pneumocystis
       carinii pneumonia is the single most important therapeutic advance for
       the HIV-infected patient. Other advances for the treatment and
       prevention of HIV-related infections should similarly improve survival
       and reduce hospital stays. Antiretroviral therapy is relatively new. The
       currently available nucleoside reverse transcriptase inhibitors have
       proven efficacy. The role of single agents or combinations is being
       established. However, this group of antivirals has limitations that make
       alternate approaches essential. Augmentation of the patient's immune
       response will likely be a key to any future successful treatment
       regimen.
 DE    Antibiotics/*THERAPEUTIC USE  Antiviral Agents/*THERAPEUTIC USE
       AIDS-Related Opportunistic Infections/*DRUG THERAPY/PREVENTION &
       CONTROL  Bacterial Infections/DRUG THERAPY/PREVENTION & CONTROL  Child
       Child, Preschool  Female  Human  HIV Infections/COMPLICATIONS/*DRUG
       THERAPY  Immunoglobulins, Intravenous/THERAPEUTIC USE  Immunosuppression
       Infant  Male  Mycoses/DRUG THERAPY/PREVENTION & CONTROL  Parasitic
       Diseases/DRUG THERAPY/PREVENTION & CONTROL  Virus Diseases/DRUG
       THERAPY/PREVENTION & CONTROL  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).