Document 0293
 DOCN  M9460293
 TI    Programmed death of T cells in human immunodeficiency virus infection.
       No correlation with progression to disease.
 DT    9404
 AU    Meyaard L; Otto SA; Keet IP; Roos MT; Miedema F; Department of Clinical
       Viro-Immunology, Central Laboratory of the; Netherlands Red Cross Blood
       Transfusion Service, Amsterdam.
 SO    J Clin Invest. 1994 Mar;93(3):982-8. Unique Identifier : AIDSLINE
       MED/94179499
 AB    Programmed death of T cells has been proposed as one of the mechanisms
       by which HIV affects immune functions in stages of infection where the
       number of infected cells is low. Indeed, in HIV-infected individuals
       both CD4+ and CD8+ T cells are primed for programmed cell death, which
       can be enhanced by polyclonal stimulation. Here, we investigated
       programmed death of T cells in all stages of HIV infection, including
       acute infection. In individuals with primary infection the number of T
       cells dying due to apoptosis was much higher than in the asymptomatic
       phase of infection and paralleled increased numbers of CD8+ cells. In
       asymptomatic HIV-infected individuals, cells were dying in increased
       percentages compared with noninfected controls, although at much lower
       numbers than during acute infection. Death of T cells was not
       quantitatively correlated with CD4+ T cell numbers or appearance of more
       cytopathic, syncytium-inducing HIV variants. Analysis of the phenotype
       of cells undergoing apoptosis revealed that cell death was not confined
       to a specific T cell subset nor correlated with expression of certain T
       cell activation markers. Our results imply that the extent of programmed
       cell death of T cells in HIV infection does not correlate with
       progression to disease.
 DE    Antigen-Presenting Cells/PHYSIOLOGY  Antigens, CD8/ANALYSIS  *Apoptosis
       Cells, Cultured  Female  Human  HIV Infections/*IMMUNOLOGY
       Immunophenotyping  Interleukin-2/PHARMACOLOGY  Leukocyte Count  Male
       Support, Non-U.S. Gov't  T-Lymphocytes/IMMUNOLOGY/*PHYSIOLOGY  JOURNAL
       ARTICLE

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