Document 0310
 DOCN  M9460310
 TI    Doxycycline pleurodesis for pneumothorax in patients with AIDS.
 DT    9404
 AU    Read CA; Reddy VD; O'Mara TE; Richardson MS; Georgetown University
       Department of Medicine, District of; Columbia General Hospital,
       Washington, DC.
 SO    Chest. 1994 Mar;105(3):823-5. Unique Identifier : AIDSLINE MED/94178009
 AB    Since first described in 1984, nontraumatic pneumothoraces in patients
       with AIDS has become more common. When compared with spontaneous
       pneumothorax in the general population, pneumothoraces in patients with
       AIDS are often complicated by prolonged air leaks as well as higher
       recurrence rates. Chemical pleurodesis has an important role in the
       management of these complications. The most experience with chemical
       pleurodesis uses tetracycline hydrochloride as the sclerosing agent;
       however, this agent is no longer available. Doxycycline has been used in
       pleurodesis of malignant effusions, but its use in managing
       pneumothoraces is limited. We present five patients who have AIDS with a
       total of seven pneumothoraces. Each patient experienced a persistent air
       leak. Six of the pneumothoraces were managed successfully with
       doxycycline. Although the follow-up period was limited, there were no
       recurrences noted and the only side effect seen was chest pain in four
       which was easily controlled with narcotics. Doxycycline sclerotherapy
       can be used effectively for pleurodesis in the management of
       nontraumatic pneumothorax in the patient with AIDS.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult
       Bleomycins/THERAPEUTIC USE  Case Report  Chest Pain/CHEMICALLY INDUCED
       Chest Tubes  Doxycycline/*THERAPEUTIC USE  Human  Incidence
       Instillation, Drug  Male  Pleura
       Pneumothorax/COMPLICATIONS/EPIDEMIOLOGY/*THERAPY  *Sclerotherapy/ADVERSE
       EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).