Document 0316
 DOCN  M9460316
 TI    AIDS and malignant mesothelioma--is there a connection?
 DT    9404
 AU    Behling CA; Wolf PL; Haghighi P; Department of Pathology, Veterans
       Administration Medical Center,; San Diego.
 SO    Chest. 1993 Apr;103(4):1268-9. Unique Identifier : AIDSLINE MED/94177939
 AB    A 35-year-old male homosexual, a former intravenous drug abuser, was
       found to be human immunodeficiency virus (HIV) positive in 1984. He
       developed AIDS in 1987 and began treatment with zidovudine in 1989. One
       year later he developed left apical pleural blebs, a pneumothorax and an
       exudative pleural effusion. A malignant mesothelioma developed at the
       pleural blebs in the left apex. He was treated with adriamycin but rapid
       progression of the malignancy occurred and he died three months later.
       At autopsy, a malignant mesothelioma, causing respiratory failure and
       death, was found. The patient had no exposure to asbestos and asbestosis
       was not present at autopsy. We postulate that the development of
       malignant mesothelioma was probably related to HIV immune suppression or
       HIV and/or cytomegalovirus or zidovudine and is a complication of AIDS
       similar to the development of other malignant neoplasms in patients with
       AIDS.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  Case Report
       Human  Lung/PATHOLOGY  Male  Mesothelioma/*COMPLICATIONS/PATHOLOGY
       Pleural Neoplasms/*COMPLICATIONS/PATHOLOGY  JOURNAL ARTICLE

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