Document 0319
 DOCN  M9460319
 TI    Strategies for laboratory HIV testing: an examination of alternative
       approaches not requiring Western blot.
 DT    9404
 AU    Sato PA; Maskill WJ; Tamashiro H; Heymann DL; Evaluation Unit, WHO
       Global Programme on AIDS, Geneva,; Switzerland.
 SO    Bull World Health Organ. 1994;72(1):129-34. Unique Identifier : AIDSLINE
       MED/94177682
 AB    Advances in laboratory tests for antibodies to human immunodeficiency
       virus (HIV) have permitted the development of alternative HIV testing
       strategies that do not require use of the Western blot approach. Three
       strategies are proposed. In strategy I, sera are tested for HIV antibody
       using an enzyme-linked immunosorbent assay (ELISA)/rapid/simple (ERS)
       test; in strategy II, sera reactive in an initial ERS test are retested
       using a second ERS test; strategy III involves retesting with a third
       ERS test all sera reactive in two previous ERS tests. Where the
       objective is identification of asymptomatic HIV-infected individuals,
       strategy III is proposed where HIV prevalences in the study population
       are < or = 10%, and strategy II at prevalences > 10%. Strategy II is
       recommended where the diagnosis of HIV-related disease requires HIV
       testing. For serosurveillance, strategy II is recommended if the
       prevalence is < or = 10%, and strategy I if the prevalences are > 10%.
       Use of strategy I is recommended for transfusion and transplantation
       safety, at any prevalence. Lower-cost laboratory HIV testing will permit
       such testing to become more widely available.
 DE    AIDS Serodiagnosis/*METHODS  Comparative Study  Enzyme-Linked
       Immunosorbent Assay/METHODS  Human  *HIV Seroprevalence
       HIV-1/IMMUNOLOGY  HIV-2/IMMUNOLOGY  Predictive Value of Tests  Quality
       Control  Sensitivity and Specificity  *Seroepidemiologic Methods
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).